Phase 1 safety and tolerability study of IMB-1018972, a novel oral modulator of substrate utilization designed to improve cardiac metabolic efficiency and bioenergetics

Background

• The heart has the highest energy demands (ATP/g tissue) of any organ to meet the demands of continual mechanical work and maintain ionic homeostasis.
• Under normoxic conditions, the majority of ATP generated is derived from mitochondrial oxidative phosphorylation following metabolism of carbon substrates, principally fatty acids (FA) and glucose.
• Cardiac metabolic remodeling and energetic impairment are hallmarks of many inherited and acquired heart muscle disorders and may promote dysfunction.

P Chamberlin et al. American College of Cardiology 2021

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