July 05, 2021
Phase 1 safety and tolerability study of IMB-1018972, a novel oral modulator of substrate utilization designed to improve cardiac metabolic efficiency and bioenergetics
- The heart has the highest energy demands (ATP/g tissue) of any organ to meet the demands of continual mechanical work and maintain ionic homeostasis.
- Under normoxic conditions, the majority of ATP generated is derived from mitochondrial oxidative phosphorylation following metabolism of carbon substrates, principally fatty acids (FA) and glucose.
- Cardiac metabolic remodeling and energetic impairment are hallmarks of many inherited and acquired heart muscle disorders and may promote dysfunction.
P Chamberlin et al. American College of Cardiology 2021