The overall prevalence of stable angina in the US is estimated at 11.0 million, i.e., app. 4% of adult population.
The traditional hemodynamic approach to reduce oxygen demand by the use of β-blockers, calcium antagonists, and nitrates is well established. The principal mechanism of achieving a reduction in oxygen demand is by decreasing blood pressure, contractility, and heart rate. However, when titrated to effect, these agents often reach a plateau of hemodynamic suppression, where adding further dose increments or agents with a similar mechanism of action confers no benefit symptomatically, whereas adverse effects increase. This loss of risk/benefit may be especially problematic in the elderly where the hemodynamic side effects limit their quality of life.
Complementary metabolic mechanisms for reducing ischemia that do not reduce oxygen demand or increase blood supply offer an alternative therapeutic target. Under normal aerobic conditions, free fatty acids (FFA) account for 60% to 90% of the energy generated in the adult heart, whereas carbohydrates contribute to 10 to 40%. During ischemia, there is a shift towards glucose metabolism, which is advantageous because, to generate the same amount of ATP, fatty acids require 10 to 15% more oxygen than is required by glucose. As ischemia increases, the myocardium increases its utilization of glucose, even though FFA oxidation remains the major energy substrate. In addition to requiring more oxygen to generate energy, an increase in the rate of FFA oxidation leads to suppression of glucose oxidation as a result of inhibition of pyruvate dehydrogenase. This leads to the accumulation of lactate and protons in the ischemic cells, acidosis, and a reduction in contractile function, in addition to a decrease in the threshold to ventricular arrhythmias. One approach to shifting the metabolism from fatty acids to glucose oxidation is by partially inhibiting fatty acid oxidation.
For more information about stable angina, please visit the NIH website.